The Los Angeles Rams (4-1) will try to extend their winning streak to three games when they take on the San Francisco 49ers (2-3) on Sunday Night Football in Week 6. The game will be held at Levi’s Stadium with kickoff set for 8:20 p.m. ET. Below, we preview the Rams-49ers Week 6 betting odds and lines and make our NFL picks and best bets.
Rams at 49ers betting odds and lines
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 7:32 p.m. ET.
- Money line: Rams -147 (bet $147, win $100) | 49ers +125 (bet $100, win $125)
- Against the spread/ATS: Rams -2 (-115) | 49ers +2 (-106)
- Over/Under: 51.5 (O: -110 | U: -110)
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